All fundamental logistical factors for a manned Mars mission will be considered. The two basic methods that will be compared are a lunar base launched mission and a mission where the launch vehicle is refueled and then launched from the International Space Station. The pros and cons of each factor will be taken into account as they relates to energy expenditure (delta V), engineering considerations, cost, politics, public perception, etc.
The mission design determines the time frame, cost, payload (weight, volumes, and number of crew), safety issues, and scientific technologies for the Mars expedition. Several designs have been researched and considered.
Mars Direct
The Mars Direct Method attempts to "travel light, live off the land and go on a shoestring budget." This method is inexpensive at $55 billion and has a quick turn around time of 10 years. In contrast, there are many safety concerns and this plan relies on a Mars in-situ propellant production.
ISS Launch
Another option is to launch from the ISS. This method requires multipule lanuches of fuel and supply to LEO and then a second launch to Mars. With this sequence, more payload can be sent to Mars (13.5 times more than payload), but the equipment will be difficult to assembe in space and there is a greater chance for failure.
Moon Base
A moon to Mars mission allows for experience to be gained on the lunar surface before attempting an extended Mars mission. This design provides long term launch and cost reduction. In the short run, this mission is energy inefficient with 35% more delta v than Mars Direct and 250% more delta v than ISS Launch.
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